Our research in the field of Regenerative Medicine has focused on the regeneration of connective tissues. Over the years we have developed a clinical and therapeutic approach dedicated to the reparative stimulation of suffering tissues by stimulating their natural regeneration capacities and restoring their correct functioning. The MSW-Villa Aurora is a new model of health care that integrates clinical, scientific and research activities in a published format (Publication attached). Clinical activity is based on a multidisciplinary approach and provides treatments aimed at improving the symptoms of the disease through tissue regeneration. The multidisciplinary team (MDT) involves the surgeon, the biologist, the laboratory technician, the radiologist, the physiotherapist and the medical director. The efficacy of care and patient safety are the foundations that define a new alliance relationship between doctor and patient. Scientific activity and Research deal with communication, training and refresher courses, with the collection of scientific data and their publication.
Learn MoreIn recent decades, research has mainly focused on the regeneration of articular cartilage, but recent acquisitions regarding the pathophysiology of early OA (initial arthrosis) have demonstrated the fundamental role of the membrane and synovial fluid which together with cartilage degeneration start the inflammatory process. and joint degenerative. Joint pain originates from the non-cartilaginous components of the joint: specifically from the capsule-synovial membrane complex and from ligament and tendon insertions where significant innervation exists. Furthermore, the initial joint pain is triggered by the SP neuropeptide secreted by the aforementioned tissues. The pathophysiology of OA together with the discoveries that emerged in Regenerative Medicine have now highlighted the reversibility of the initial disease as reported in our publication (attached publication).
Learn MoreResident-resident MSCs- Mesenchymal Stem Cells are the therapeutic target of Regenerative Medicine procedures and their correct stimulation is decisive for triggering the reparative process. Our studies helped determine the localization and mapping of resident MSCs present in the joint. Furthermore, in 2012 the author published some works describing a new procedure based on the local stimulation of joint resident MSCs. The aim of the study was the long-term control of OA symptoms through the recovery of local cellular homeostasis and then tissue repair. Gel repair is an individual drug produced from the patient's blood and is made up of polydeoxyribonucleotides (PDRN), Heat Shock Proteins (HSPs) and a glycerol scaffold. Gel repair works as an activator of the resident MSCs located in the capsule and in the synovial tissue. A 3-year follow-up observational trial demonstrated persistent symptom improvement in over 80% of treated patients along with frequent radiological downstaging of OA.
Learn MoreIn recent years L-PRF (leukocyte and platelet-rich fibrin) has been shown to have marked regenerative properties on connective tissues. In particular it has been used in the treatment of chronic skin ulcers and in the regeneration of the jaw bone in implantology. After centrifugation, the blood produces L-PRF membranes and hyper-acute serum. These components variously contain a high concentration of living cells: leukocytes, platelets and circulating MSCs (Periferal blood derived-MSCs) - a variable pool of anti-inflammatory cytokines - a high concentration of various growth factors (GFs): PDGF AB, VEGF , TGF β-1,2; IGF-I, EGF, CTGF, BMP-2 - a high concentration of fibrin, fibronectin, vitronectin and thrombospondin - a variable pool of heat shock proteins HSPs. Since 2018 we have been using L-PRF in degenerative arthropathy and we have published some preliminary results.
Learn Morethe experimental and clinical use of Omentum adipose stem cells (OAST) are part of our ongoing research portfolio. The biological properties of Omento include: haemostasis, neovascularization, immunomodulation and infection control, and tissue regeneration. The omentum has been shown to be an in vivo incubator for cell and tissue cultivation. OAST autotransplantation opens up new perspectives in connective tissue regeneration. So far we have sporadically used OAST in intestinal anastomoses, in the regeneration of the anal sphincter complex; as a nutritional and regenerative support of the dermis in chronic skin ulcers and, in Orthopedics, in the treatment of complications from prosthetic infection.
Learn MoreThis new inguinal hernia repair technique uses L-PRF to fix the prosthetic mesh without using traditional sutures. Preliminary results show us how this procedure results in less postoperative pain, the absence of nerve entrapment syndrome and chronic groin pain (11% in literature), and finally, a faster recovery time for normal activities. The integration time of the mesh is reduced as well as scarring fibrosis to the advantage of the formation of linear collagen 1-2 and restoration of normal connective tissue.
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